7SXF

BIO-2895 (BRD0705) bound GSK3alpha-axin complex

Summary for 7SXF

Entry DOI	10.2210/pdb7sxf/pdb
Descriptor	Glycogen synthase kinase-3 alpha, Axin peptide, (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, ... (5 entities in total)
Functional Keywords	kinase, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	41663.10
Authors	Chodaparambil, J.V. (deposition date: 2021-11-23, release date: 2023-06-14, Last modification date: 2023-11-15)
Primary citation	Amaral, B.,Capacci, A.,Anderson, T.,Tezer, C.,Bajrami, B.,Lulla, M.,Lucas, B.,Chodaparambil, J.V.,Marcotte, D.,Kumar, P.R.,Murugan, P.,Spilker, K.,Cullivan, M.,Wang, T.,Peterson, A.C.,Enyedy, I.,Ma, B.,Chen, T.,Yousaf, Z.,Calhoun, M.,Golonzhka, O.,Dillon, G.M.,Koirala, S. Elucidation of the GSK3 alpha Structure Informs the Design of Novel, Paralog-Selective Inhibitors. Acs Chem Neurosci, 14:1080-1094, 2023 Cited by PubMed: 36812145 DOI: 10.1021/acschemneuro.2c00476 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation