7ST5
Structure of Fab CC-95251 in complex with SIRP-alpha
Summary for 7ST5
Entry DOI | 10.2210/pdb7st5/pdb |
Descriptor | Fab CC-95251 anti-SIRP-alpha heavy chain, Fab CC-95251 anti-SIRP-alpha light chain, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (6 entities in total) |
Functional Keywords | cell surface receptor, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 122338.78 |
Authors | Fenalti, G. (deposition date: 2021-11-12, release date: 2023-05-17, Last modification date: 2023-10-25) |
Primary citation | Fenalti, G. Discovery and preclinical activity of CC-95251, a SIRP-alpha antibody mediating tumor cell phagocytosis, in combination with target therapies To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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