7SRS

5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM)

7SRS の概要

• エントリーDOI: 10.2210/pdb7srs/pdb
• EMDBエントリー: 25403
• 分子名称: Anti-5HT2BR Fab light chain, Anti-5HT2BR Fab heavy chain, 5-hydroxytryptamine receptor 2B, ... (8 entities in total)
• 機能のキーワード: 5-ht2b receptor, serotonin receptor, beta-arrestin1, arrestin, gpcr, lysergic acid diethylamide, lsd, cryoem, membrane protein
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 150383.41

構造登録者

Barros-Alvarez, X.,Cao, C.,Panova, O.,Roth, B.L.,Skiniotis, G. (登録日: 2021-11-08, 公開日: 2022-09-21, 最終更新日: 2022-10-19)

• 主引用文献: Cao, C.,Barros-Alvarez, X.,Zhang, S.,Kim, K.,Damgen, M.A.,Panova, O.,Suomivuori, C.M.,Fay, J.F.,Zhong, X.,Krumm, B.E.,Gumpper, R.H.,Seven, A.B.,Robertson, M.J.,Krogan, N.J.,Huttenhain, R.,Nichols, D.E.,Dror, R.O.,Skiniotis, G.,Roth, B.L.; Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.; Neuron, 110:3154-, 2022; PubMed: 36087581; DOI: 10.1016/j.neuron.2022.08.006

実験手法

ELECTRON MICROSCOPY (3.3 Å)