7SQL

Crystal structure of human uridine-cytidine kinase 2 complexed with a weak small molecule inhibitor

7SQL の概要

• エントリーDOI: 10.2210/pdb7sql/pdb
• 分子名称: Uridine-cytidine kinase 2, TRIETHYLENE GLYCOL, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: kinase, uridine kinase, cytidine kinase, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 114759.47

構造登録者

Mashayekh, S.,Stunkard, L.M.,Kienle, M.,Mathews, I.I.,Khosla, C. (登録日: 2021-11-05, 公開日: 2022-10-12, 最終更新日: 2023-10-25)

• 主引用文献: Mashayekh, S.,Stunkard, L.M.,Kienle, M.,Mathews, I.I.,Khosla, C.; Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2).; Biochemistry, 61:2261-2266, 2022; PubMed: 36190114; DOI: 10.1021/acs.biochem.2c00451

実験手法

X-RAY DIFFRACTION (2.4 Å)