7SQ9

Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution

7SQ9 の概要

• エントリーDOI: 10.2210/pdb7sq9/pdb
• EMDBエントリー: 25380
• 分子名称: Mucolipin-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, ... (6 entities in total)
• 機能のキーワード: ion channel, membrane protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 271145.46

構造登録者

Gan, N.,Han, Y.,Jiang, Y. (登録日: 2021-11-04, 公開日: 2022-02-02, 最終更新日: 2022-02-23)

• 主引用文献: Gan, N.,Han, Y.,Zeng, W.,Wang, Y.,Xue, J.,Jiang, Y.; Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.; Proc.Natl.Acad.Sci.USA, 119:-, 2022; PubMed: 35131932; DOI: 10.1073/pnas.2120404119

実験手法

ELECTRON MICROSCOPY (2.11 Å)