7SPS
Crystal structure of human glucose transporter GLUT3 bound with exofacial inhibitor SA47
Summary for 7SPS
Entry DOI | 10.2210/pdb7sps/pdb |
Descriptor | Solute carrier family 2, facilitated glucose transporter member 3, methyl N-[(2-{4-[4-(5-fluoro-2-methoxyphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}phenyl)methyl]-beta-alaninate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total) |
Functional Keywords | mfs, hexose transporter, inhibitor, transport protein-inhibitor complex, transport protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 116637.68 |
Authors | |
Primary citation | Wang, N.,Zhang, S.,Yuan, Y.,Xu, H.,Defossa, E.,Matter, H.,Besenius, M.,Derdau, V.,Dreyer, M.,Halland, N.,He, K.H.,Petry, S.,Podeschwa, M.,Tennagels, N.,Jiang, X.,Yan, N. Molecular basis for inhibiting human glucose transporters by exofacial inhibitors. Nat Commun, 13:2632-2632, 2022 Cited by PubMed: 35552392DOI: 10.1038/s41467-022-30326-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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