7SPS
Crystal structure of human glucose transporter GLUT3 bound with exofacial inhibitor SA47
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Solute carrier family 2, facilitated glucose transporter member 3 | polymer | 523 | 56907.9 | 2 | UniProt (P11169) Pfam (PF00083) In PDB | Homo sapiens (Human) | Glucose transporter type 3,brain,GLUT-3 |
2 | A, B | methyl N-[(2-{4-[4-(5-fluoro-2-methoxyphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}phenyl)methyl]-beta-alaninate | non-polymer | 519.6 | 2 | Chemie (A0E) | |||
3 | A, B | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 5 | Chemie (OLC) | |||
4 | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 496 (UniProt: P11169)
PDB | External Database | Details |
---|---|---|
Met -26 | - | expression tag |
His -25 | - | expression tag |
His -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
Ser -15 | - | expression tag |
Gly -14 | - | expression tag |
Asp -13 | - | expression tag |
Glu -12 | - | expression tag |
Val -11 | - | expression tag |
Asp -10 | - | expression tag |
Ala -9 | - | expression tag |
Gly -8 | - | expression tag |
Ser -7 | - | expression tag |
Gly -6 | - | expression tag |
Gln -5 | - | expression tag |
Val -4 | - | expression tag |
Asp -3 | - | expression tag |
Ala -2 | - | expression tag |
Gly -1 | - | expression tag |
Thr 0 | - | expression tag |
Thr 43 | Asn 43 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 113815.8 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2821.8 | |
All* | Total formula weight | 116637.7 |