7SIM

Structure of positive allosteric modulator-free active human calcium-sensing receptor

Summary for 7SIM

• Entry DOI: 10.2210/pdb7sim/pdb
• EMDB information: 25144
• Descriptor: Isoform 1 of Extracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: calcium-sensing receptor, cryo-em structure, allosteric modulation, activation mechanism, symmetry, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 204775.21

Authors

Park, J.,Zuo, H.,Frangaj, A.,Fu, Z.,Yen, L.Y.,Zhang, Z.,Mosyak, L.,Slavkovich, V.N.,Liu, J.,Ray, K.M.,Cao, B.,Vallese, F.,Geng, Y.,Chen, S.,Grassucci, R.,Dandey, V.P.,Tan, Y.Z.,Eng, E.,Lee, Y.,Kloss, B.,Liu, Z.,Hendrickson, W.A.,Potter, C.S.,Carragher, B.,Graziano, J.,Conigrave, A.D.,Frank, J.,Clarke, O.B.,Fan, Q.R. (deposition date: 2021-10-14, release date: 2022-01-19)

• Primary citation: Park, J.,Zuo, H.,Frangaj, A.,Fu, Z.,Yen, L.Y.,Zhang, Z.,Mosyak, L.,Slavkovich, V.N.,Liu, J.,Ray, K.M.,Cao, B.,Vallese, F.,Geng, Y.,Chen, S.,Grassucci, R.,Dandey, V.P.,Tan, Y.Z.,Eng, E.,Lee, Y.,Kloss, B.,Liu, Z.,Hendrickson, W.A.,Potter, C.S.,Carragher, B.,Graziano, J.,Conigrave, A.D.,Frank, J.,Clarke, O.B.,Fan, Q.R.; Symmetric activation and modulation of the human calcium-sensing receptor.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34916296; DOI: 10.1073/pnas.2115849118

Experimental method

ELECTRON MICROSCOPY (2.7 Å)