7SIM

Structure of positive allosteric modulator-free active human calcium-sensing receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Isoform 1 of Extracellular calcium-sensing receptor	polymer	878	99299.5	2	UniProt (P41180-1) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) UniProt (by SIFTS) (P41180) In PDB	Homo sapiens (Human)	CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1
2	C, D, E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
3	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	A, B	CYCLOMETHYLTRYPTOPHAN	non-polymer		216.2	2	Chemie (TCR)
5	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
6	A, B	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)
7	B, A	CHOLESTEROL	non-polymer		386.7	8	Chemie (CLR)

Sequence modifications

A, B: 1 - 870 (UniProt: P41180-1)

PDB	External Database	Details
Asp 871	-	expression tag
Tyr 872	-	expression tag
Lys 873	-	expression tag
Asp 874	-	expression tag
Asp 875	-	expression tag
Asp 876	-	expression tag
Asp 877	-	expression tag
Lys 878	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	198598.9
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	22
	Total formula weight	4478.7
All*	Total formula weight	204775.2

*Water molecules are not included.