7SHE

Cryo-EM structure of human GPR158

Summary for 7SHE

Entry DOI	10.2210/pdb7she/pdb
EMDB information	25125 25126
Descriptor	G-protein coupled receptor 158, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, (2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate, ... (4 entities in total)
Functional Keywords	receptor, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	186640.82
Authors	Patil, D.N.,Singh, S.,Singh, A.K.,Martemyanov, K.A. (deposition date: 2021-10-08, release date: 2021-12-01, Last modification date: 2022-01-19)
Primary citation	Patil, D.N.,Singh, S.,Laboute, T.,Strutzenberg, T.S.,Qiu, X.,Wu, D.,Novick, S.J.,Robinson, C.V.,Griffin, P.R.,Hunt, J.F.,Izard, T.,Singh, A.K.,Martemyanov, K.A. Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex. Science, 375:86-91, 2022 Cited by PubMed: 34793198 DOI: 10.1126/science.abl4732 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation