7SEO

Crystal Structure of Caspase-3 with Peptide Inhibitor Ac-VDV(DAB)D-CHO

Summary for 7SEO

Entry DOI	10.2210/pdb7seo/pdb
Descriptor	Caspase-3 subunit p17, Caspase-3 subunit p12, ACE-VAL-ASP-VAL-DAB-ASP, ... (4 entities in total)
Functional Keywords	protease, inhibitor, covalent, apoptosis
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	56710.75
Authors	Fuller, J.L.,Finzel, B.C. (deposition date: 2021-09-30, release date: 2022-01-05, Last modification date: 2023-10-18)
Primary citation	Bresinsky, M.,Strasser, J.M.,Vallaster, B.,Liu, P.,McCue, W.M.,Fuller, J.,Hubmann, A.,Singh, G.,Nelson, K.M.,Cuellar, M.E.,Wilmot, C.M.,Finzel, B.C.,Ashe, K.H.,Walters, M.A.,Pockes, S. Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314. Acs Pharmacol Transl Sci, 5:20-40, 2022 Cited by PubMed: 35059567 DOI: 10.1021/acsptsci.1c00251 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation