7S8C

Cryo-EM structure of human TRPV6 in complex with inhibitor econazole

Summary for 7S8C

• Entry DOI: 10.2210/pdb7s8c/pdb
• Related: 7S88 7S89 7S8B
• EMDB information: 24890 24891 24892 24893
• Descriptor: Transient receptor potential cation channel subfamily V member 6, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CHOLESTEROL HEMISUCCINATE, ... (6 entities in total)
• Functional Keywords: transient receptor potential v family member 6, trp, channel, econazole, inhibitor, antagonist, cnw11, nanodiscs, trpv6, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 333289.51

Authors

Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2021-09-17, release date: 2021-11-17, Last modification date: 2024-06-05)

• Primary citation: Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I.; Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.; Nat Commun, 12:6284-6284, 2021; PubMed: 34725357; DOI: 10.1038/s41467-021-26608-x

Experimental method

ELECTRON MICROSCOPY (2.85 Å)