7S8C

Cryo-EM structure of human TRPV6 in complex with inhibitor econazole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Transient receptor potential cation channel subfamily V member 6	polymer	683	78421.3	4	UniProt (Q9H1D0) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) In PDB	Homo sapiens (Human)	TrpV6,CaT-like,CaT-L,Calcium transport protein 1,CaT1,Epithelial calcium channel 2,ECaC2
2	A, D, B, C	1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole	non-polymer		381.7	4	Chemie (ECL)
3	A, D, B, C	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	12	Chemie (Y01)
4	C, D, A, B	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	16	Chemie (POV)
5	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
6	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)

Sequence modifications

A, B, C, D: 1 - 667 (UniProt: Q9H1D0)

PDB	External Database	Details
Val 668	-	expression tag
Pro 669	-	expression tag
Arg 670	-	expression tag
Gly 671	-	expression tag
Ser 672	-	expression tag
Ala 673	-	expression tag
Ala 674	-	expression tag
Ala 675	-	expression tag
Trp 676	-	expression tag
Ser 677	-	expression tag
His 678	-	expression tag
Pro 679	-	expression tag
Gln 680	-	expression tag
Phe 681	-	expression tag
Glu 682	-	expression tag
Lys 683	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	313685.3
Non-Polymers*	Number of molecules	34
	Total formula weight	19604.2
All*	Total formula weight	333289.5

*Water molecules are not included.