7S8B
Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red
Summary for 7S8B
Entry DOI | 10.2210/pdb7s8b/pdb |
Related | 7S88 7S89 |
EMDB information | 24890 24891 24892 |
Descriptor | Transient receptor potential cation channel subfamily V member 6, CHOLESTEROL HEMISUCCINATE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (6 entities in total) |
Functional Keywords | transient receptor potential v family member 6, trp, channel, ruthenium red, channel blocker, antagonist, cnw11, nanodiscs, trpv6, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 344556.24 |
Authors | Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2021-09-17, release date: 2021-11-17, Last modification date: 2024-06-05) |
Primary citation | Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12:6284-6284, 2021 Cited by PubMed: 34725357DOI: 10.1038/s41467-021-26608-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.43 Å) |
Structure validation
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