7S8B

Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transient receptor potential cation channel subfamily V member 6	polymer	683	78421.3	4	UniProt (Q9H1D0) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520)	Homo sapiens (Human)	TrpV6,CaT-like,CaT-L,Calcium transport protein 1,CaT1,Epithelial calcium channel 2,ECaC2
2	CA, E, EA, F, FA... (C, A, D, B)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	12	Chemie (Y01)
3	G, GA, UA, V (A, C, D, B)	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		787.1	4	Chemie (PCW)
4	AA, BA, DA, H, HA... (B, C, A, D)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	28	Chemie (POV)
5	P (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
6	Q (A)	ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)	non-polymer		559.5	1	Chemie (R2R)

Sequence modifications

A, B, C, D: 1 - 667 (UniProt: Q9H1D0)

PDB	External Database	Details
Val 668	-	expression tag
Pro 669	-	expression tag
Arg 670	-	expression tag
Gly 671	-	expression tag
Ser 672	-	expression tag
Ala 673	-	expression tag
Ala 674	-	expression tag
Ala 675	-	expression tag
Trp 676	-	expression tag
Ser 677	-	expression tag
His 678	-	expression tag
Pro 679	-	expression tag
Gln 680	-	expression tag
Phe 681	-	expression tag
Glu 682	-	expression tag
Lys 683	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	313685.3
Non-Polymers*	Number of molecules	46
	Total formula weight	30870.9
All*	Total formula weight	344556.2

*Water molecules are not included.