7S8B
Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Transient receptor potential cation channel subfamily V member 6 | polymer | 683 | 78421.3 | 4 | UniProt (Q9H1D0) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) In PDB | Homo sapiens (Human) | TrpV6,CaT-like,CaT-L,Calcium transport protein 1,CaT1,Epithelial calcium channel 2,ECaC2 |
| 2 | C, A, D, B | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 12 | Chemie (Y01) | |||
| 3 | A, C, D, B | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 4 | Chemie (PCW) | |||
| 4 | B, C, A, D | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 28 | Chemie (POV) | |||
| 5 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | A | ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | non-polymer | 559.5 | 1 | Chemie (R2R) |
Sequence modifications
A, B, C, D: 1 - 667 (UniProt: Q9H1D0)
| PDB | External Database | Details |
|---|---|---|
| Val 668 | - | expression tag |
| Pro 669 | - | expression tag |
| Arg 670 | - | expression tag |
| Gly 671 | - | expression tag |
| Ser 672 | - | expression tag |
| Ala 673 | - | expression tag |
| Ala 674 | - | expression tag |
| Ala 675 | - | expression tag |
| Trp 676 | - | expression tag |
| Ser 677 | - | expression tag |
| His 678 | - | expression tag |
| Pro 679 | - | expression tag |
| Gln 680 | - | expression tag |
| Phe 681 | - | expression tag |
| Glu 682 | - | expression tag |
| Lys 683 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 313685.3 | |
| Non-Polymers* | Number of molecules | 46 |
| Total formula weight | 30870.9 | |
| All* | Total formula weight | 344556.2 |
