7S87
Crystal Structure of Dihydroorotate dehydrogenase from Plasmodium falciparum in complex with Orotate, FMN, and inhibitor NCGC00600348-01
Summary for 7S87
Entry DOI | 10.2210/pdb7s87/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, (4R)-3-methyl-5-[(4R)-4-methyl-3,4-dihydroisoquinolin-2(1H)-yl]thieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine, FLAVIN MONONUCLEOTIDE, ... (8 entities in total) |
Functional Keywords | inhibitor, dhodh, tim barrel, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Plasmodium falciparum (isolate 3D7) |
Total number of polymer chains | 2 |
Total formula weight | 94252.39 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-09-17, release date: 2021-09-29, Last modification date: 2023-10-18) |
Primary citation | Seattle Structural Genomics Center for Infectious Disease (SSGCID),Shek, R.,Abendroth, J.,Lorimer, D.,Edwards, T.E.,Eastman, R.,Van Voorhis, W. Crystal Structure of Dihydroorotate dehydrogenase from Plasmodium falciparum in complex with Orotate, FMN, and inhibitor NCGC00600348-01 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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