7S87
Crystal Structure of Dihydroorotate dehydrogenase from Plasmodium falciparum in complex with Orotate, FMN, and inhibitor NCGC00600348-01
7S87 の概要
エントリーDOI | 10.2210/pdb7s87/pdb |
分子名称 | Dihydroorotate dehydrogenase (quinone), mitochondrial, (4R)-3-methyl-5-[(4R)-4-methyl-3,4-dihydroisoquinolin-2(1H)-yl]thieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine, FLAVIN MONONUCLEOTIDE, ... (8 entities in total) |
機能のキーワード | inhibitor, dhodh, tim barrel, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Plasmodium falciparum (isolate 3D7) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 94252.39 |
構造登録者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2021-09-17, 公開日: 2021-09-29, 最終更新日: 2023-10-18) |
主引用文献 | Seattle Structural Genomics Center for Infectious Disease (SSGCID),Shek, R.,Abendroth, J.,Lorimer, D.,Edwards, T.E.,Eastman, R.,Van Voorhis, W. Crystal Structure of Dihydroorotate dehydrogenase from Plasmodium falciparum in complex with Orotate, FMN, and inhibitor NCGC00600348-01 To Be Published, |
実験手法 | X-RAY DIFFRACTION (2.75 Å) |
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