7S6D
CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure
Summary for 7S6D
Entry DOI | 10.2210/pdb7s6d/pdb |
EMDB information | 24869 24870 24871 24872 24873 24874 24875 |
Descriptor | 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Lsd14 Polyketide synthase fusion, Fab 1B2 heavy chain, Fab 1B2 light chain, ... (4 entities in total) |
Functional Keywords | modular polyketide synthase, ketosynthase, ketoreductase, acyl carrier protein, biosynthetic protein |
Biological source | Saccharopolyspora erythraea More |
Total number of polymer chains | 7 |
Total formula weight | 627091.27 |
Authors | Bagde, S.R.,Kim, C.-Y.,Fromme, J.C. (deposition date: 2021-09-13, release date: 2021-11-03, Last modification date: 2021-11-17) |
Primary citation | Bagde, S.R.,Mathews, I.I.,Fromme, J.C.,Kim, C.Y. Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374:723-729, 2021 Cited by PubMed: 34735234DOI: 10.1126/science.abi8532 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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