7S15

GLP-1 receptor bound with Pfizer small molecule agonist

7S15 の概要

• エントリーDOI: 10.2210/pdb7s15/pdb
• EMDBエントリー: 24794
• 分子名称: Glucagon-like peptide 1 receptor, 2-[(4-{6-[(2,4-difluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H-benzimidazole-6-carboxylic acid (2 entities in total)
• 機能のキーワード: glp-1r, gpcr, membrane protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47287.64

構造登録者

Liu, Y.,Dias, J.M.,Han, S. (登録日: 2021-09-01, 公開日: 2022-06-08, 最終更新日: 2022-07-06)

• 主引用文献: Griffith, D.A.,Edmonds, D.J.,Fortin, J.P.,Kalgutkar, A.S.,Kuzmiski, J.B.,Loria, P.M.,Saxena, A.R.,Bagley, S.W.,Buckeridge, C.,Curto, J.M.,Derksen, D.R.,Dias, J.M.,Griffor, M.C.,Han, S.,Jackson, V.M.,Landis, M.S.,Lettiere, D.,Limberakis, C.,Liu, Y.,Mathiowetz, A.M.,Patel, J.C.,Piotrowski, D.W.,Price, D.A.,Ruggeri, R.B.,Tess, D.A.; A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.; J.Med.Chem., 65:8208-8226, 2022; PubMed: 35647711; DOI: 10.1021/acs.jmedchem.1c01856

実験手法

ELECTRON MICROSCOPY (3.8 Å)