7RXW

Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor imido-diphosphate (PNP)

7RXW の概要

• エントリーDOI: 10.2210/pdb7rxw/pdb
• 関連するPDBエントリー: 7L1A 7RXV 7RXX
• 分子名称: S-adenosylmethionine synthase isoform type-2, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALANINE, ... (8 entities in total)
• 機能のキーワード: sam synthetase, enzyme mechanism, inhibitor, transition state, transferase-inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46992.54

構造登録者

Fedorov, E.,Niland, C.N.,Schramm, V.L.,Ghosh, A. (登録日: 2021-08-23, 公開日: 2021-11-10, 最終更新日: 2023-10-18)

• 主引用文献: Ghosh, A.,Niland, C.N.,Cahill, S.M.,Karadkhelkar, N.M.,Schramm, V.L.; Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 angstrom Resolution.; J.Am.Chem.Soc., 143:18325-18330, 2021; PubMed: 34668717; DOI: 10.1021/jacs.1c09328

実験手法

X-RAY DIFFRACTION (1.07 Å)