7RNM
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with 2-(2-Chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)isoindolin-5-ol and GRIP Peptide
Summary for 7RNM
Entry DOI | 10.2210/pdb7rnm/pdb |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, 2-(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-isoindol-5-ol, ... (4 entities in total) |
Functional Keywords | breast cancer, estrogen receptor, alpha helical bundle, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 60193.72 |
Authors | Joiner, C.,Sammeta, V.K.R.,Norris, J.D.,McDonnell, D.P.,Willson, T.M.,Fanning, S.W. (deposition date: 2021-07-29, release date: 2022-08-03, Last modification date: 2024-02-14) |
Primary citation | Reddy Sammeta, V.,Anderson, B.M.,Norris, J.D.,Torrice, C.D.,Joiner, C.,Liu, S.,Li, H.,Popov, K.I.,Fanning, S.W.,McDonnell, D.P.,Willson, T.M. Structural Determinants of the Binding and Activation of Estrogen Receptor alpha by Phenolic Thieno[2,3-d]pyrimidines Helv.Chim.Acta, 106:-, 2023 Cited by DOI: 10.1002/hlca.202300097PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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