7RNM
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with 2-(2-Chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)isoindolin-5-ol and GRIP Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 250 | 28440.5 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 10 | 1276.5 | 2 | UniProt (E7EWM1) | Homo sapiens (Human) | |
| 3 | E, F (A, B) | 2-(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-isoindol-5-ol | non-polymer | 379.9 | 2 | Chemie (61Z) | |||
| 4 | G, H, I (A, B, D) | water | water | 18.0 | 378 | Chemie (HOH) |
Sequence modifications
A, B: 305 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 59434.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 759.7 | |
| All* | Total formula weight | 60193.7 |
