7RLO

Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs

7RLO の概要

• エントリーDOI: 10.2210/pdb7rlo/pdb
• EMDBエントリー: 24535
• 分子名称: Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... (6 entities in total)
• 機能のキーワード: complex, viral protein, integrated stress response, protein translation, translation
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 583746.17

構造登録者

Wang, L.,Schoof, M.,Cogan, J.,Lawrence, R.,Boone, M.,Wuerth, J.,Frost, M.,Walter, P. (登録日: 2021-07-26, 公開日: 2021-12-22)

• 主引用文献: Schoof, M.,Wang, L.,Cogan, J.Z.,Lawrence, R.E.,Boone, M.,Wuerth, J.D.,Frost, A.,Walter, P.; Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B.; Nat Commun, 12:7103-7103, 2021; PubMed: 34876554; DOI: 10.1038/s41467-021-26164-4

実験手法

ELECTRON MICROSCOPY (2.6 Å)