7RIE

Plasmodium falciparum M17 in complex with inhibitor MIPS2571

Summary for 7RIE

Entry DOI	10.2210/pdb7rie/pdb
Descriptor	M17 leucyl aminopeptidase, CARBONATE ION, ZINC ION, ... (7 entities in total)
Functional Keywords	aminopeptidase, enzyme, malaria, peptide binding protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum
Total number of polymer chains	12
Total formula weight	712701.43
Authors	Webb, C.T.,McGowan, S. (deposition date: 2021-07-19, release date: 2022-09-14, Last modification date: 2023-10-25)
Primary citation	Edgar, R.C.S.,Siddiqui, G.,Hjerrild, K.,Malcolm, T.R.,Vinh, N.B.,Webb, C.T.,Holmes, C.,MacRaild, C.A.,Chernih, H.C.,Suen, W.W.,Counihan, N.A.,Creek, D.J.,Scammells, P.J.,McGowan, S.,de Koning-Ward, T.F. Genetic and chemical validation of Plasmodium falciparum aminopeptidase Pf A-M17 as a drug target in the hemoglobin digestion pathway. Elife, 11:-, 2022 Cited by PubMed: 36097817 DOI: 10.7554/eLife.80813 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation