7RFL

CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor SGC0946

Summary for 7RFL

• Entry DOI: 10.2210/pdb7rfl/pdb
• Descriptor: Site-specific DNA-methyltransferase (adenine-specific), DNA Strand 2, DNA Strand 1, ... (7 entities in total)
• Functional Keywords: dna adenine methylation, protein-dna complex, transferase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Clostridioides difficile (Peptoclostridium difficile); More
• Total number of polymer chains: 9
• Total formula weight: 234885.11

Authors

Horton, J.R.,Cheng, X.,Zhou, J. (deposition date: 2021-07-14, release date: 2021-09-15, Last modification date: 2023-10-18)

• Primary citation: Zhou, J.,Horton, J.R.,Yu, D.,Ren, R.,Blumenthal, R.M.,Zhang, X.,Cheng, X.; Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA.; Epigenetics, 17:970-981, 2022; PubMed: 34523387; DOI: 10.1080/15592294.2021.1976910

Experimental method

X-RAY DIFFRACTION (2.38 Å)