7REE

High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to YM2-059

Summary for 7REE

• Entry DOI: 10.2210/pdb7ree/pdb
• Descriptor: Tyrosine-protein kinase JAK2, [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile (3 entities in total)
• Functional Keywords: kinase, janus kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35538.55

Authors

Karim, M.R.,Schonbrunn, E. (deposition date: 2021-07-12, release date: 2021-09-01, Last modification date: 2023-11-15)

• Primary citation: Karim, M.R.,Schonbrunn, E.; High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to YM2-059.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.38 Å)