7REE
High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to YM2-059
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase JAK2 | polymer | 297 | 34944.9 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | A | [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile | non-polymer | 593.7 | 1 | Chemie (4LY) | |||
| 3 | water | water | 18.0 | 371 | Chemie (HOH) |
Sequence modifications
A: 839 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Ala 836 | - | expression tag |
| Phe 837 | - | expression tag |
| Ala 838 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34944.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 593.7 | |
| All* | Total formula weight | 35538.5 |
