7R7J

Crystal structure of RadD with ADP

7R7J の概要

• エントリーDOI: 10.2210/pdb7r7j/pdb
• 関連するPDBエントリー: 6JDE
• 分子名称: Putative DNA repair helicase RadD, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: atpase, sf2, dna binding protein
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 134182.73

構造登録者

Osorio Garcia, M.A.,Satyshur, K.A.,Keck, J.L.,Cox, M.M. (登録日: 2021-06-24, 公開日: 2022-04-13, 最終更新日: 2023-10-18)

主引用文献

Osorio Garcia, M.A.,Satyshur, K.A.,Cox, M.M.,Keck, J.L.
X-ray crystal structure of the Escherichia coli RadD DNA repair protein bound to ADP reveals a novel zinc ribbon domain.
Plos One, 17:e0266031-e0266031, 2022

PubMed Abstract: Genome maintenance is an essential process in all cells. In prokaryotes, the RadD protein is important for survival under conditions that include DNA-damaging radiation. Precisely how RadD participates in genome maintenance remains unclear. Here we present a high-resolution X-ray crystal structure of ADP-bound Escherichia coli RadD, revealing a zinc-ribbon element that was not modelled in a previous RadD crystal structure. Insights into the mode of nucleotide binding and additional structure refinement afforded by the new RadD model will help to drive investigations into the activity of RadD as a genome stability and repair factor.

PubMed: 35482735
DOI: 10.1371/journal.pone.0266031

実験手法

X-RAY DIFFRACTION (2.03 Å)