7R5X

Tankyrase 2 in complex with an inhibitor (OUL211)

This is a non-PDB format compatible entry.

Summary for 7R5X

• Entry DOI: 10.2210/pdb7r5x/pdb
• Descriptor: Poly [ADP-ribose] polymerase tankyrase-2, 7-methyl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole, ZINC ION, ... (7 entities in total)
• Functional Keywords: inhibitor, complex, adp-ribosylation, enzyme, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 50677.82

Authors

Sowa, S.T.,Lehtio, L. (deposition date: 2022-02-11, release date: 2023-02-08, Last modification date: 2024-02-07)

• Primary citation: Murthy, S.,Nizi, M.G.,Maksimainen, M.M.,Massari, S.,Alaviuhkola, J.,Lippok, B.E.,Vagaggini, C.,Sowa, S.T.,Galera-Prat, A.,Ashok, Y.,Venkannagari, H.,Prunskaite-Hyyrylainen, R.,Dreassi, E.,Luscher, B.,Korn, P.,Tabarrini, O.,Lehtio, L.; [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.; J.Med.Chem., 66:1301-1320, 2023; PubMed: 36598465; DOI: 10.1021/acs.jmedchem.2c01460

Experimental method

X-RAY DIFFRACTION (2.052 Å)