7QQG

Crystal structure of MYORG bound to 1-deoxygalactonojirimycin

Summary for 7QQG

Entry DOI	10.2210/pdb7qqg/pdb
Related	7QQF 7QQH
Descriptor	Myogenesis-regulating glycosidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	gh31, glycoside hydrolase, myorg, net37, galactosidase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	296038.74
Authors	Meek, R.W.,Davies, G.J. (deposition date: 2022-01-07, release date: 2022-08-31, Last modification date: 2024-01-31)
Primary citation	Meek, R.W.,Brockerman, J.,Fordwour, O.B.,Zandberg, W.F.,Davies, G.J.,Vocadlo, D.J. The primary familial brain calcification-associated protein MYORG is an alpha-galactosidase with restricted substrate specificity. Plos Biol., 20:e3001764-e3001764, 2022 Cited by PubMed: 36129849 DOI: 10.1371/journal.pbio.3001764 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation