7QG6

Co-crystal structure of UPF3A-RRM-NOPS-L with UPF2-MIF4GIII

Summary for 7QG6

Entry DOI	10.2210/pdb7qg6/pdb
Descriptor	Regulator of nonsense transcripts 3A, Regulator of nonsense transcripts 2, TRIETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywords	nonsense mediated mrna decay neurological development x-linked intellectual disability up-frameshift proteins, rna binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	234971.47
Authors	Powers, K.T.,Bufton, J.C.,Szeto, J.A.,Schaffitzel, C. (deposition date: 2021-12-07, release date: 2022-07-20, Last modification date: 2024-01-31)
Primary citation	Bufton, J.C.,Powers, K.T.,Szeto, J.A.,Toelzer, C.,Berger, I.,Schaffitzel, C. Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation. Nucleic Acids Res., 50:5934-5947, 2022 Cited by PubMed: 35640974 DOI: 10.1093/nar/gkac421 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation