7QG6
Co-crystal structure of UPF3A-RRM-NOPS-L with UPF2-MIF4GIII
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (C, A, E, G) | Regulator of nonsense transcripts 3A | polymer | 176 | 20829.6 | 4 | UniProt (Q9H1J1) Pfam (PF03467) | Homo sapiens (human) | Nonsense mRNA reducing factor 3A,Up-frameshift suppressor 3 homolog A,hUpf3 |
| 2 | B, D, F, H (D, B, F, H) | Regulator of nonsense transcripts 2 | polymer | 321 | 37791.8 | 4 | UniProt (Q9HAU5) Pfam (PF02854) | Homo sapiens (human) | Up-frameshift suppressor 2 homolog,hUpf2 |
| 3 | I, J, K (D, B, F) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 4 | L (F) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | M, N, O, P, Q... (C, D, A, B, F...) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
C, A, E, G: 58 - 206 (UniProt: Q9H1J1)
D, B, F, H: 761 - 1054 (UniProt: Q9HAU5)
| PDB | External Database | Details |
|---|---|---|
| Met 31 | - | initiating methionine |
| Ser 32 | - | expression tag |
| Tyr 33 | - | expression tag |
| Tyr 34 | - | expression tag |
| His 35 | - | expression tag |
| His 36 | - | expression tag |
| His 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| Asp 41 | - | expression tag |
| Tyr 42 | - | expression tag |
| Asp 43 | - | expression tag |
| Ile 44 | - | expression tag |
| Pro 45 | - | expression tag |
| Thr 46 | - | expression tag |
| Thr 47 | - | expression tag |
| Glu 48 | - | expression tag |
| Asn 49 | - | expression tag |
| Leu 50 | - | expression tag |
| Tyr 51 | - | expression tag |
| Phe 52 | - | expression tag |
| Gln 53 | - | expression tag |
| Gly 54 | - | expression tag |
| Ala 55 | - | expression tag |
| Met 56 | - | expression tag |
| Asp 57 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 734 | - | initiating methionine |
| Ser 735 | - | expression tag |
| Tyr 736 | - | expression tag |
| Tyr 737 | - | expression tag |
| His 738 | - | expression tag |
| His 739 | - | expression tag |
| His 740 | - | expression tag |
| His 741 | - | expression tag |
| His 742 | - | expression tag |
| His 743 | - | expression tag |
| Asp 744 | - | expression tag |
| Tyr 745 | - | expression tag |
| Asp 746 | - | expression tag |
| Ile 747 | - | expression tag |
| Pro 748 | - | expression tag |
| Thr 749 | - | expression tag |
| Thr 750 | - | expression tag |
| Glu 751 | - | expression tag |
| Asn 752 | - | expression tag |
| Leu 753 | - | expression tag |
| Tyr 754 | - | expression tag |
| Phe 755 | - | expression tag |
| Gln 756 | - | expression tag |
| Gly 757 | - | expression tag |
| Ala 758 | - | expression tag |
| Met 759 | - | expression tag |
| Asp 760 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 234485.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 486.0 | |
| All* | Total formula weight | 234971.5 |
