7QG1
IRAK4 in complex with inhibitor
Summary for 7QG1
Entry DOI | 10.2210/pdb7qg1/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]-5-oxidanylidene-pyrido[4,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate (3 entities in total) |
Functional Keywords | kinase inhibitor interleukin-1 receptor-associated kinase 4 interleukin-1 signaling, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 74097.34 |
Authors | Xue, Y.,Aagaard, A.,Robb, G.R.,Degorce, S.L. (deposition date: 2021-12-07, release date: 2022-05-04, Last modification date: 2024-01-31) |
Primary citation | Cumming, I.A.,Degorce, S.L.,Aagaard, A.,Braybrooke, E.L.,Davies, N.L.,Diene, C.R.,Eatherton, A.J.,Felstead, H.R.,Groombridge, S.D.,Lenz, E.M.,Li, Y.,Nai, Y.,Pearson, S.,Robb, G.R.,Scott, J.S.,Steward, O.R.,Wu, C.,Xue, Y.,Zhang, L.,Zhang, Y. Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors. Bioorg.Med.Chem., 63:116729-116729, 2022 Cited by PubMed: 35439688DOI: 10.1016/j.bmc.2022.116729 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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