7QG1

IRAK4 in complex with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Interleukin-1 receptor-associated kinase 4	polymer	322	36528.1	2	UniProt (Q9NWZ3) Pfam (PF07714)	Homo sapiens (Human)	IRAK-4,Renal carcinoma antigen NY-REN-64
2	C, D (A, B)	methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]-5-oxidanylidene-pyrido[4,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate	non-polymer		520.6	2	Chemie (B8I)
3	E, F (A, B)	water	water		18.0	239	Chemie (HOH)

Sequence modifications

A, B: 154 - 460 (UniProt: Q9NWZ3)

PDB	External Database	Details
Met 139	-	initiating methionine
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
Glu 147	-	expression tag
Asn 148	-	expression tag
Leu 149	-	expression tag
Tyr 150	-	expression tag
Phe 151	-	expression tag
Gln 152	-	expression tag
Gly 153	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	73056.2
Non-Polymers*	Number of molecules	2
	Total formula weight	1041.2
All*	Total formula weight	74097.3

*Water molecules are not included.