7QFV

Crystal structure of KLK6 in complex with compound 17a

This is a non-PDB format compatible entry.

Summary for 7QFV

• Entry DOI: 10.2210/pdb7qfv/pdb
• Related: 7QFT
• Descriptor: Kallikrein-6, KLK6 Activity-Based Probe (Ahx-DPhe-Ser(Z)-Dht-Arg-DPP) (3 entities in total)
• Functional Keywords: serine proteases, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 50813.65

Authors

Jagtap, P.K.A.,Zhang, L.,De Vita, E.,Tate, E.W.,Hennig, J. (deposition date: 2021-12-06, release date: 2022-10-26, Last modification date: 2024-01-31)

• Primary citation: Zhang, L.,Lovell, S.,De Vita, E.,Jagtap, P.K.A.,Lucy, D.,Goya Grocin, A.,Kjaer, S.,Borg, A.,Hennig, J.,Miller, A.K.,Tate, E.W.; A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion.; J.Am.Chem.Soc., 144:22493-22504, 2022; PubMed: 36413626; DOI: 10.1021/jacs.2c07378

Experimental method

X-RAY DIFFRACTION (1.56 Å)