7QFT
Crystal structure of KLK6 in complex with compound 16a
This is a non-PDB format compatible entry.
Summary for 7QFT
| Entry DOI | 10.2210/pdb7qft/pdb |
| Descriptor | Kallikrein-6, KLK6 Activity-Based Probe (Ahx-DPhe-Cha-Dht-Arg-DPP) (3 entities in total) |
| Functional Keywords | serine proteases, peptide binding protein |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 50765.69 |
| Authors | Jagtap, P.K.A.,Zhang, L.,De Vita, E.,Tate, E.W.,Hennig, J. (deposition date: 2021-12-06, release date: 2022-11-09, Last modification date: 2024-01-31) |
| Primary citation | Zhang, L.,Lovell, S.,De Vita, E.,Jagtap, P.K.A.,Lucy, D.,Goya Grocin, A.,Kjaer, S.,Borg, A.,Hennig, J.,Miller, A.K.,Tate, E.W. A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion. J.Am.Chem.Soc., 144:22493-22504, 2022 Cited by PubMed: 36413626DOI: 10.1021/jacs.2c07378 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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