7QDN

Structure of human liver pyruvate kinase from which the B domain has been deleted

Summary for 7QDN

• Entry DOI: 10.2210/pdb7qdn/pdb
• Descriptor: Pyruvate kinase PKLR, 1,6-di-O-phosphono-beta-D-fructofuranose, OXALIC ACID, ... (7 entities in total)
• Functional Keywords: pkl, pyruvate kinase, glycolysis, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 390369.40

Authors

Lulla, A.,Hyvonen, M. (deposition date: 2021-11-27, release date: 2022-03-30, Last modification date: 2024-01-31)

• Primary citation: Nain-Perez, A.,Foller Fuchtbauer, A.,Haversen, L.,Lulla, A.,Gao, C.,Matic, J.,Monjas, L.,Rodriguez, A.,Brear, P.,Kim, W.,Hyvonen, M.,Boren, J.,Mardinoglu, A.,Uhlen, M.,Grotli, M.; Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.; Eur.J.Med.Chem., 234:114270-114270, 2022; PubMed: 35290845; DOI: 10.1016/j.ejmech.2022.114270

Experimental method

X-RAY DIFFRACTION (1.695 Å)