7QDN

Structure of human liver pyruvate kinase from which the B domain has been deleted

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Pyruvate kinase PKLR	polymer	447	48285.4	8	UniProt (P30613) Pfam (PF00224) Pfam (PF02887)	Homo sapiens (Human)	Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase
2	BA, FA, I, KA, M... (E, F, A, G, B...)	1,6-di-O-phosphono-beta-D-fructofuranose	non-polymer		340.1	8	Chemie (FBP)
3	CA, GA, J, LA, N... (E, F, A, G, B...)	OXALIC ACID	non-polymer		90.0	8	Chemie (OXD)
4	DA, HA, K, MA, O... (E, F, A, G, B...)	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
5	EA, IA, L, NA, P... (E, F, A, G, B...)	POTASSIUM ION	non-polymer		39.1	8	Chemie (K)
6	AA, JA, OA, Q, TA... (D, F, G, B, H...)	SODIUM ION	non-polymer		23.0	6	Chemie (NA)
7	AB, BB, UA, VA, WA... (G, H, A, B, C...)	water	water		18.0	2562	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: -1 - 543 (UniProt: P30613)

PDB	External Database	Details
Ser 0	Ala 31	conflict
Met 1	Pro 32	conflict
Glu 2	Gly 33	conflict
Asp 12	Ser 43	conflict
-	Glu 161	deletion
-	Ile 162	deletion
-	Arg 163	deletion
-	Thr 164	deletion
-	Gly 165	deletion
-	Ile 166	deletion
-	Leu 167	deletion
-	Gln 168	deletion
-	Gly 169	deletion
-	Gly 170	deletion
-	Pro 171	deletion
-	Glu 172	deletion
-	Ser 173	deletion
-	Glu 174	deletion
-	Val 175	deletion
-	Glu 176	deletion
-	Leu 177	deletion
-	Val 178	deletion
-	Lys 179	deletion
-	Gly 180	deletion
-	Ser 181	deletion
-	Gln 182	deletion
-	Val 183	deletion
-	Leu 184	deletion
-	Val 185	deletion
-	Thr 186	deletion
-	Val 187	deletion
-	Asp 188	deletion
-	Pro 189	deletion
-	Ala 190	deletion
-	Phe 191	deletion
-	Arg 192	deletion
-	Thr 193	deletion
-	Arg 194	deletion
-	Gly 195	deletion
-	Asn 196	deletion
-	Ala 197	deletion
-	Asn 198	deletion
-	Thr 199	deletion
-	Val 200	deletion
-	Trp 201	deletion
-	Val 202	deletion
-	Asp 203	deletion
-	Tyr 204	deletion
-	Pro 205	deletion
-	Asn 206	deletion
-	Ile 207	deletion
-	Val 208	deletion
-	Arg 209	deletion
-	Val 210	deletion
-	Val 211	deletion
-	Pro 212	deletion
-	Val 213	deletion
-	Gly 214	deletion
-	Gly 215	deletion
-	Arg 216	deletion
-	Ile 217	deletion
-	Tyr 218	deletion
-	Ile 219	deletion
-	Asp 220	deletion
-	Asp 221	deletion
-	Gly 222	deletion
-	Leu 223	deletion
-	Ile 224	deletion
-	Ser 225	deletion
-	Leu 226	deletion
-	Val 227	deletion
-	Val 228	deletion
-	Gln 229	deletion
-	Lys 230	deletion
-	Ile 231	deletion
-	Gly 232	deletion
-	Pro 233	deletion
-	Glu 234	deletion
-	Gly 235	deletion
-	Leu 236	deletion
-	Val 237	deletion
-	Thr 238	deletion
-	Gln 239	deletion
-	Val 240	deletion
-	Glu 241	deletion
-	Asn 242	deletion
-	Gly 243	deletion
-	Gly 244	deletion
-	Val 245	deletion
-	Leu 246	deletion
-	Gly 247	deletion
-	Ser 248	deletion
-	Arg 249	deletion
-	Lys 250	deletion
-	Gly 251	deletion
-	Val 252	deletion
-	Asn 253	deletion
-	Leu 254	deletion
-	Pro 255	deletion
-	Gly 256	deletion
-	Ala 257	deletion
-	Gln 258	deletion
Gly 130	Val 259	conflict
Ser 131	Asp 260	conflict
Gly 132	Leu 261	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	386283.0
Non-Polymers*	Number of molecules	38
	Total formula weight	4086.4
All*	Total formula weight	390369.4

*Water molecules are not included.