7QA0
Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound 1456
Summary for 7QA0
Entry DOI | 10.2210/pdb7qa0/pdb |
Descriptor | Multiple virulence factor regulator MvfR, ~{N}-[[2-(3-chloranyl-4-propan-2-yloxy-phenyl)-1,3-thiazol-5-yl]methyl]-2-(trifluoromethyl)pyridin-4-amine (3 entities in total) |
Functional Keywords | quorum sensing, lysr-type transcriptional regulator, pseudomonas, 2 quinolone signaling system, lttr, dna binding protein, gene regulation |
Biological source | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Total number of polymer chains | 2 |
Total formula weight | 75370.70 |
Authors | Schmelz, S.,Blankenfeldt, W. (deposition date: 2021-11-15, release date: 2022-11-23, Last modification date: 2024-01-31) |
Primary citation | Blankenfeldt, W.,Schmelz, S. Divergent Synthesis and Biological Evaluation of inverse agonists targeting PqsR To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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