7Q3P

Crystal structure of IgG1-Fc-MST-HN (efgartigimod)

7Q3P の概要

• エントリーDOI: 10.2210/pdb7q3p/pdb
• 分子名称: IgG1-Fc-MST-HN, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: fc, igg1-fc-mst-hn, efgartigimod, argx-113, fcrn, fcrn-binding protein, immune system
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 81025.70

構造登録者

Pannecoucke, E.,Savvides, S.N. (登録日: 2021-10-28, 公開日: 2022-09-28, 最終更新日: 2024-01-31)

• 主引用文献: Brinkhaus, M.,Pannecoucke, E.,van der Kooi, E.J.,Bentlage, A.E.H.,Derksen, N.I.L.,Andries, J.,Balbino, B.,Sips, M.,Ulrichts, P.,Verheesen, P.,de Haard, H.,Rispens, T.,Savvides, S.N.,Vidarsson, G.; The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.; Nat Commun, 13:6073-6073, 2022; PubMed: 36241613; DOI: 10.1038/s41467-022-33764-1

実験手法

X-RAY DIFFRACTION (2.1 Å)