7Q3N

Cryo-EM of the complex between human uromodulin (UMOD)/Tamm-Horsfall protein (THP) and the FimH lectin domain from uropathogenic E. coli

7Q3N の概要

• エントリーDOI: 10.2210/pdb7q3n/pdb
• 関連するPDBエントリー: 6GTW 6TQK 7PFP
• EMDBエントリー: 10553 13378 13794
• 分子名称: Uromodulin, Type 1 fimbiral adhesin FimH, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: egf domain, decoy module, beta-hairpin, d10c domain, d8c domain, extracellular matrix, glycoprotein, n-glycan, high-mannose sugar, cell adhesion, antimicrobial protein, bacterial adhesin, type i pilus, sugar binding protein, lectin, urinary tract infection, uti, uropathogenic e. coli, upec
• 由来する生物種: Escherichia coli (strain UTI89 / UPEC); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83877.90

構造登録者

Jovine, L.,Xu, C.,Stsiapanava, A.,Carroni, M.,Tunyasuvunakool, K.,Jumper, J.,Wu, B. (登録日: 2021-10-28, 公開日: 2022-03-16, 最終更新日: 2022-03-30)

• 主引用文献: Stsiapanava, A.,Xu, C.,Nishio, S.,Han, L.,Yamakawa, N.,Carroni, M.,Tunyasuvunakool, K.,Jumper, J.,de Sanctis, D.,Wu, B.,Jovine, L.; Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.; Nat.Struct.Mol.Biol., 29:190-193, 2022; PubMed: 35273390; DOI: 10.1038/s41594-022-00729-3

実験手法

ELECTRON MICROSCOPY (7.4 Å)