7Q2J

Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer

7Q2J の概要

• エントリーDOI: 10.2210/pdb7q2j/pdb
• 分子名称: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (6 entities in total)
• 機能のキーワード: protac, wdr5, vhl, quaternary complex, structural genomics, structural genomics consortium, sgc, structural protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 80528.52

構造登録者

Kraemer, A.,Doelle, A.,Schwalm, M.P.,Adhikari, B.,Wolf, E.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2021-10-25, 公開日: 2021-11-24, 最終更新日: 2024-01-31)

• 主引用文献: Schwalm, M.P.,Kramer, A.,Dolle, A.,Weckesser, J.,Yu, X.,Jin, J.,Saxena, K.,Knapp, S.; Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization.; Cell Chem Biol, 30:753-765.e8, 2023; PubMed: 37354907; DOI: 10.1016/j.chembiol.2023.06.002

実験手法

X-RAY DIFFRACTION (2.5 Å)