7Q1C

Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor

Summary for 7Q1C

Entry DOI	10.2210/pdb7q1c/pdb
Descriptor	Histone deacetylase DAC2, ZINC ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	epigenetics, trypanosoma cruzi, histone deacetylase, dac2, pathogen, hydrolase
Biological source	Trypanosoma cruzi
Total number of polymer chains	2
Total formula weight	101611.21
Authors	Ramos-Morales, E.,Marek, M.,Romier, C. (deposition date: 2021-10-18, release date: 2021-12-15, Last modification date: 2024-01-31)
Primary citation	Marek, M.,Ramos-Morales, E.,Picchi-Constante, G.F.A.,Bayer, T.,Norstrom, C.,Herp, D.,Sales-Junior, P.A.,Guerra-Slompo, E.P.,Hausmann, K.,Chakrabarti, A.,Shaik, T.B.,Merz, A.,Troesch, E.,Schmidtkunz, K.,Goldenberg, S.,Pierce, R.J.,Mourao, M.M.,Jung, M.,Schultz, J.,Sippl, W.,Zanchin, N.I.T.,Romier, C. Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Rep, 37:110129-110129, 2021 Cited by PubMed: 34936867 DOI: 10.1016/j.celrep.2021.110129 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation