7PX3

Structure of U5 snRNP assembly and recycling factor TSSC4 in complex with BRR2 and Jab1 domain of PRPF8

Summary for 7PX3

Entry DOI	10.2210/pdb7px3/pdb
EMDB information	13690
Descriptor	U5 small nuclear ribonucleoprotein 200 kDa helicase, Pre-mRNA-processing-splicing factor 8, Protein TSSC4 (3 entities in total)
Functional Keywords	spliceosomal biogenesis, splicing
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	264166.35
Authors	Bergfort, A.,Kuropka, B.,Ilik, I.A.,Freund, C.,Aktas, T.,Hilal, T.,Weber, G.,Wahl, M.C. (deposition date: 2021-10-07, release date: 2022-01-26, Last modification date: 2024-07-17)
Primary citation	Bergfort, A.,Hilal, T.,Kuropka, B.,Ilik, I.A.,Weber, G.,Aktas, T.,Freund, C.,Wahl, M.C. The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Res., 50:2938-2958, 2022 Cited by PubMed: 35188580 DOI: 10.1093/nar/gkac087 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.05 Å)

Structure validation