7PWY

Structure of human dimeric ACMSD in complex with the inhibitor TES-1025

7PWY の概要

• エントリーDOI: 10.2210/pdb7pwy/pdb
• 分子名称: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, ZINC ION, 2-[3-[(5-cyano-6-oxidanylidene-4-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanylmethyl]phenyl]ethanoic acid, ... (5 entities in total)
• 機能のキーワード: acmsd, de-novo nad+ synthesis, tes-1025, decarboxylase, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 153600.00

構造登録者

Cianci, M.,Giacche, N.,Carotti, A.,Liscio, P.,Amici, A.,Cialabrini, L.,De Franco, F.,Pellicciari, R.,Raffaelli, N. (登録日: 2021-10-07, 公開日: 2022-04-20, 最終更新日: 2024-01-31)

• 主引用文献: Cianci, M.,Giacche, N.,Cialabrini, L.,Carotti, A.,Liscio, P.,Rosatelli, E.,De Franco, F.,Gasparrini, M.,Robertson, J.,Amici, A.,Raffaelli, N.,Pellicciari, R.; Structural Basis of Human Dimeric alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase Inhibition With TES-1025.; Front Mol Biosci, 9:834700-834700, 2022; PubMed: 35463964; DOI: 10.3389/fmolb.2022.834700

実験手法

X-RAY DIFFRACTION (2.5 Å)