7PW6

Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body

Summary for 7PW6

• Entry DOI: 10.2210/pdb7pw6/pdb
• EMDB information: 13676
• Descriptor: Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1, INOSITOL HEXAKISPHOSPHATE, 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (3 entities in total)
• Functional Keywords: complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 322128.08

Authors

Langer, L.M.,Conti, E. (deposition date: 2021-10-06, release date: 2021-12-01)

• Primary citation: Langer, L.M.,Bonneau, F.,Gat, Y.,Conti, E.; Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.; Elife, 10:-, 2021; PubMed: 34698635; DOI: 10.7554/eLife.72353

Experimental method

ELECTRON MICROSCOPY (3.05 Å)