7PW6

Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body

7PW6 の概要

• エントリーDOI: 10.2210/pdb7pw6/pdb
• EMDBエントリー: 13676
• 分子名称: Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1, INOSITOL HEXAKISPHOSPHATE, 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (3 entities in total)
• 機能のキーワード: complex, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 322128.08

構造登録者

Langer, L.M.,Conti, E. (登録日: 2021-10-06, 公開日: 2021-12-01)

• 主引用文献: Langer, L.M.,Bonneau, F.,Gat, Y.,Conti, E.; Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.; Elife, 10:-, 2021; PubMed: 34698635; DOI: 10.7554/eLife.72353

実験手法

ELECTRON MICROSCOPY (3.05 Å)