7PT4

Actinobacterial 2-hydroxyacyl-CoA lyase (AcHACL) structure in complex with a covalently bound reaction intermediate as well as products formyl-CoA and acetone

Summary for 7PT4

Entry DOI	10.2210/pdb7pt4/pdb
Descriptor	2-hydroxyacyl-CoA lyase, THIAMINE DIPHOSPHATE, SULFATE ION, ... (8 entities in total)
Functional Keywords	thdp, coa, lyase
Biological source	Actinomycetospora chiangmaiensis DSM 45062
Total number of polymer chains	2
Total formula weight	135146.52
Authors	Zahn, M.,Rohwerder, T. (deposition date: 2021-09-25, release date: 2022-02-02, Last modification date: 2024-01-31)
Primary citation	Zahn, M.,Konig, G.,Pham, H.V.C.,Seroka, B.,Lazny, R.,Yang, G.,Ouerfelli, O.,Lotowski, Z.,Rohwerder, T. Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA. J.Biol.Chem., 298:101522-101522, 2022 Cited by PubMed: 34952003 DOI: 10.1016/j.jbc.2021.101522 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation