7PQV

MEK1 IN COMPLEX WITH COMPOUND 7

Summary for 7PQV

Entry DOI	10.2210/pdb7pqv/pdb
Descriptor	Dual specificity mitogen-activated protein kinase kinase 1, 8-(2-chloranyl-4-methoxy-phenyl)-7-fluoranyl-1-piperidin-4-yl-imidazo[4,5-c]quinoline, CALCIUM ION, ... (5 entities in total)
Functional Keywords	mek1 mitogen-activated protein kinase 1, kinase inhibitor, anti-cancer drug, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	39022.75
Authors	Moebitz, H. (deposition date: 2021-09-20, release date: 2022-03-16, Last modification date: 2022-03-23)
Primary citation	Poddutoori, R.,Aardalen, K.,Aithal, K.,Barahagar, S.S.,Belliappa, C.,Bock, M.,Chelur, S.,Gerken, A.,Gopinath, S.,Gruenenfelder, B.,Kiffe, M.,Krishnaswami, M.,Langowski, J.,Madapa, S.,Narayanan, K.,Pandit, C.,Panigrahi, S.K.,Perrone, M.,Potakamuri, R.K.,Ramachandra, M.,Ramanathan, A.,Ramos, R.,Sager, E.,Samajdar, S.,Subramanya, H.S.,Thimmasandra, D.S.,Venetsanakos, E.,Mobitz, H. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action. J.Med.Chem., 65:4350-4366, 2022 Cited by PubMed: 35195996 DOI: 10.1021/acs.jmedchem.1c02192 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation