7PQV
MEK1 IN COMPLEX WITH COMPOUND 7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 344 | 38507.4 | 1 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (Human) | MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 2 | B (A) | 8-(2-chloranyl-4-methoxy-phenyl)-7-fluoranyl-1-piperidin-4-yl-imidazo[4,5-c]quinoline | non-polymer | 410.9 | 1 | Chemie (80C) | |||
| 3 | C, D (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | F (A) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A: 39 - 382 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Asn 298 | Ser 298 | conflict |
| Lys 299 | Ser 299 | conflict |
| Phe 300 | Tyr 300 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38507.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 515.3 | |
| All* | Total formula weight | 39022.7 |
